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Sepsis

FOAMEd Wiki - Sepsis, last updated 4/12/25

Sepsis Guidelines and Protocols	Source	Year
Sepsis and Septic Shock: Emergency Medicine Cases	EM Cases	2019
Sepsis Protocol Pitfalls: SGEM#346	SGEM	2021
Surviving Sepsis Campaign 2021 Updates (emDocs)	emDocs	2021
Surviving Sepsis Campaign 2021 Updates (JournalFeed)	JournalFeed	2021
Surviving Sepsis Campaign: 2021 Guidelines	Critical Care Medicine	2021
Protocolised Management in Sepsis: ARISE and PROCESS Trials	RebelEM	2015
Protocolised Management in Sepsis: PROMISE Trial	RebelEM	2015

Antibiotics and Timing	Source	Year
REBEL Cast Ep70: Time to Antibiotics in Sepsis	REBEL EM	2018
Time to Antibiotics in Sepsis: Immediate vs. Delayed	JournalFeed $	2020
Vancomycin or β-lactam First for Bacteremia?	JournalFeed $	2021

Fluids: Bolus, Responsiveness, and Restriction	Source	Year
Bolus: The Dark Side of Fluid Resuscitation	EMCrit	2017
FRESH Trial: Fluid Responsiveness Evaluation	JournalFeed $	2020
Fluid Administration in ESRD for Severe Sepsis	REBEL EM	2018
Fluid Responsiveness and the Six Guiding Principles	REBEL EM	2015
Passive Leg Raise Test for Fluid Responsiveness	JournalFeed $	2020
Restrictive Fluid in Septic Shock (RIFTS RCT)	JournalFeed $	2019
The CLASSIC Trial: IV Fluid Restriction in Septic Shock	REBEL EM	2022
When Your Septic Patient Isn’t Improving After IV Fluids	emDocs	2016

Hemodynamic Management	Source	Year
CENSER Trial: Early Norepinephrine in Septic Shock	REBEL EM	2019
Esmolol for Septic Shock	JournalFeed $	2021

Steroids and Metabolic Cocktail	Source	Year
ACTS Trial: Thiamine, Ascorbic Acid, and Hydrocortisone in Septic Shock	REBEL EM	2020
ADRENAL: Hydrocortisone in Septic Shock	JournalFeed $	2018
CITRIS-ALI: Vitamin C in Sepsis and ARDS	REBEL EM	2019
Hydrocortisone and Fludrocortisone in Septic Shock (APROCCHSS)	JournalFeed $	2018
HYVCTTSSS RCT: Vitamin C, Thiamine, and Steroids in Sepsis	JournalFeed $	2020
HYVCTTSSS Trial: The Metabolic Cocktail in Another RCT	REBEL EM	2020
Steroids in Septic Shock: BMJ Rapid Recommendation	BMJ	2018
Steroids in Septic Shock: Evidence Update	REBEL EM	2019
The VICTAS Trial: How Many Metabolic Cocktails Do We Need?	REBEL EM	2021

Scoring Systems	Source	Year
Early Sepsis Screening in the Emergency Department	REBEL EM	2017
NEWS Score (National Early Warning Score)	MDCalc
QSOFA Score (Quick SOFA)	MDCalc
SIRS vs. qSOFA: The Confusion in Sepsis	REBEL EM	2017

Other Topics	Source	Year
Lactate Myths in Sepsis	EMCrit	2018
Think Sepsis: Considerations Beyond Lung and Urine	emDocs	2016

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